Fei Wang ^a,b,*, Mei-Fen Mao ^b, Guo-Zhu Wei ^b, Yuan Gao ^b, Fu-Cai Ren ^b, Ji-Kai Liu ^a,*

^a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China

^b BioBioPha Co., Ltd., 132 Lanhei Road, Kunming 650201, China

Abstract

Two Daphniphyllum alkaloid and iridoid hybrids with the hitherto unknown decacyclic fused skeletons, hybridaphniphyllines A and B, along with one diamino Daphniphyllum alkaloid, daphnicyclidin I, were isolated from dried stems and leaves of Daphniphyllum longeracemosum. Their structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configuration of daphnicyclidin I was deduced by the CD exciton chirality method. A biogenetic pathway for 1 and 2 involving natural Diels–Alder cycloaddition is proposed.

文章链接：https://sciencedirect.xilesou.top/science/article/abs/pii/S0031942213002598