Fei Wang ^†,§, Yuan Gao ^§, Ling Zhang ^†, Bing Bai ^†, Ya Nan Hu ^‡, Ze Jun Dong ^†, Qi Wei Zhai ^*,‡, Hua Jie Zhu ^*,†, and Ji Kai Liu ^*,†

^† State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People’s Republic of China 

^§ BioBioPha Co. Ltd., Kunming 650204, People’s Republic of China

^‡ Institute for Nutritional Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Tai-Yuan Road, Shanghai 200031, People’s Republic of China

Abstract

(+)-Linderaspirone A and (-)-linderaspirone A, a pair of natural windmill-shaped enantiomers, were isolated from the traditional Chinese medicine plant Lindera aggregate by HPLC using a chiral column, achieving over 98% ee. Their structures and absolute configurations were determined on the basis of extensive analysis of NMR spectra, crystal X-ray diffraction, and calculation of the optical rotations (OR). They have an unprecedented carbon skeleton and showed significant activity against glucosamine-induced insulin resistance.

文章链接：https://pubs.acs.org/doi/abs/10.1021/ol1011289