Yuan Gao . Yan-Fen Niu . Fei Wang . Ping Hai . Fang Wang . Yin-Dong Fang . Wen-Yong Xiong . Ji-Kai Liu

Received: 30 August 2016 / Accepted: 28 September 2016 / Published online: 17 October 2016

© The Author(s) 2016. This article is published with open access at Springerlink.com

Abstract

Four new clerodane diterpenoids, tinosporols A–C (2–4) and tinosporoside A (5), together with six known analogues were isolated from the vines of Tinospora crispa. Their structures were established by extensive spectroscopic analysis. The relative configuration at C-12 in the known diterpenoid borapetoside E (1), the major component of the plant, was firstly established with the aid of molecular model. Compound 1 significantly reduced serum glucose levels at dose-dependent manners in alloxan-induced hyperglycemic mice and db/db type 2 diabetic mice.

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