Xiang-Mei Li . Xian-Jun Jiang . Ku Yang . Li-Xia Wang . Shi-Zhen Wen . Fei Wang

Received: 3 September 2016 / Accepted: 8 September 2016 / Published online: 19 September 2016

© The Author(s) 2016. This article is published with open access at Springerlink.com

Abstract

Four hitherto unknown prenylated coumarins, namely 6’’-O-β-D-apiofuranosylapterin (1), 4’-O-isobutyroylpeguangxienin (2), 6-(3-methyl-2-oxobutyroyl)-7-methoxycoumarin (3), and 6-hydroxycoumurrayin (4), were isolated from the ethanol extract of Heracleum stenopterum, Peucedanum praeruptorum, Clausena lansium, and Murraya paniculata, respectively. Their chemical structures were established on the basis of extensive spectroscopic analysis. Compound 2 exhibited in vitro cytotoxic activity against five human cancer cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW-480) with IC₅₀ values ranging from 15.9 to 23.2 μM.

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